HMGXB3

Across TCGA patient cohorts, HMGXB3 mutation is significantly associated with the total protein of many other genes, with 26 significant associations in total. COAD shows the largest number of these associations.

The most reproducible HMGXB3-associated genes across cancer lineages are MSH6, eIF4E, and eIF4G. Each is linked with HMGXB3 in more than 2 cancer types. Because this analysis shows association rather than direction, both HMGXB3-to-partner and partner-to-HMGXB3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MSH6 grouped by HMGXB3-low versus HMGXB3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HMGXB3→partner) and Y-score (partner→HMGXB3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MSH6 →	-0.361	-2.459	.002	.018	3	3
UCEC	eIF4E →	+0.293	+3.713	<.001	<.001	3	2
COAD	eIF4G →	-1.070	-2.991	<.001	.036	3	2
COAD	Gab2 →	-0.531	-2.974	.001	.036	3	2
COAD	mTOR_pS2448 →	-0.213	-2.991	.021	.036	3	2
COAD	Tuberin →	-0.605	-2.991	<.001	.036	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 26 associations by consensus.

MSH6 by HMGXB3 expression — UCEC

Explore this box plot interactively →