HMGN2P28

Across TCGA pan-cancer cohorts, HMGN2P28 RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated HMGN2P28 data layer.

The strongest signal is observed in skin cutaneous melanoma (SKCM), where higher HMGN2P28 RNA is associated with better overall survival. In most high-consensus cancer types, elevated HMGN2P28 expression acts as an unfavorable survival marker, although some lineages such as SKCM and KIRC show a favorable association.

SKCM, ACC, and LGG are the cancer types where HMGN2P28 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SKCM	OS	Median	All	0.835	0.726	<.001	96	view →
ACC	DFS	Tertile	All	0.374	0.729	<.001	62	view →
LGG	DFS	Tertile	All	0.757	0.893	<.001	33	view →
KIRC	DFS	Quartile	All	0.860	0.687	.010	24	view →
KICH	DFS	Quartile	All	0.575	1.000	.001	22	view →
ESCA	OS	Median	All	0.412	0.573	.029	22	view →
LUSC	OS	Quartile	All	0.859	0.701	.001	21	view →
MESO	DFS	Median	III,IV	0.232	0.608	.034	12	view →
PRAD	DFS	Tertile	All	0.883	0.743	.018	12	view →
LUAD	OS	Median	III,IV	0.596	0.424	.023	10	view →
PAAD	DFS	Tertile	All	0.387	0.574	.028	9	view →
SARC	OS	Quartile	All	0.384	0.725	.006	8	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

HMGN2P28–SKCM (OS)

Open the SKCM breakdown →