HMGN2P28

Across TCGA pan-cancer cohorts, HMGN2P28 RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of HMGN2P28’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where HMGN2P28 RNA is repressed in tumor relative to normal tissue. In most cancer types HMGN2P28 is over-expressed in tumor, although a few such as THCA and COAD show the opposite, repressed pattern.

THCA, CHOL, and COAD are the cancer types where HMGN2P28 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in HMGN2P28 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Female	All	−0.403	<.001	7	view →
CHOL	Male	All	+0.835	.012	4	view →
COAD	Female	All	−0.397	.008	3	view →
KICH	All	All	−0.381	.002	3	view →
KIRP	Male	All	−0.231	.029	3	view →
STAD	All	II,III,IV	+0.434	.025	2	view →
PRAD	All	All	+0.330	.005	2	view →
LUSC	Female	III,IV	+0.280	.017	1	view →
LIHC	All	All	+0.143	.034	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

HMGN2P28–THCA

Open the THCA breakdown →