HMGN2P27

Across TCGA pan-cancer cohorts, HMGN2P27 RNA differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of HMGN2P27’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where HMGN2P27 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types HMGN2P27 is over-expressed in tumor, although a few such as KICH show the opposite, repressed pattern.

HNSC, LIHC, and KICH are the cancer types where HMGN2P27 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in HMGN2P27 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	II,III,IV	+0.142	.011	5	view →
LIHC	All	II,III,IV	+0.107	.014	4	view →
KICH	Female	II,III,IV	−0.205	.003	2	view →
BRCA	Female	All	+0.182	.033	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

HMGN2P27–HNSC

Open the HNSC breakdown →