HMGN2P23

Across TCGA pan-cancer cohorts, HMGN2P23 RNA is linked to patient survival in 19 of 34 cancer types, making it the most broadly survival-associated HMGN2P23 data layer.

The strongest signal is observed in mesothelioma (MESO), where higher HMGN2P23 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated HMGN2P23 expression acts as an unfavorable survival marker, although some lineages such as COAD and ESCA show a favorable association.

MESO, LIHC, and ACC are the cancer types where HMGN2P23 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
MESO	OS	Tertile	All	0.299	0.613	<.001	108	view →
LIHC	DFS	Tertile	All	0.277	0.461	.001	36	view →
ACC	DFS	Quartile	All	0.178	0.560	<.001	36	view →
KIRP	DFS	Tertile	II,III,IV	0.149	0.702	.012	24	view →
COAD	DFS	Tertile	All	0.862	0.486	.009	24	view →
CESC	DFS	Median	IV	0.090	0.430	.019	24	view →
ESCA	OS	Tertile	III,IV	0.699	0.439	.012	19	view →
KIRC	OS	Tertile	All	0.777	0.592	.007	18	view →
LUAD	OS	Tertile	All	0.758	0.838	.012	13	view →
THCA	DFS	Median	III,IV	0.981	0.884	.022	12	view →
DLBC	OS	Median	IV	1.000	0.527	.033	6	view →
LGG	DFS	Tertile	All	0.743	0.873	.019	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 19 lineages.

HMGN2P23–MESO (OS)

Open the MESO breakdown →