HMGN2P23

Across TCGA pan-cancer cohorts, HMGN2P23 RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of HMGN2P23’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where HMGN2P23 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types HMGN2P23 is over-expressed in tumor, although a few such as COAD show the opposite, repressed pattern.

HNSC, BLCA, and BRCA are the cancer types where HMGN2P23 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in HMGN2P23 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	All	+0.505	.002	5	view →
BLCA	All	IV	+0.200	.002	4	view →
BRCA	All	All	+0.039	.015	4	view →
LUSC	All	All	+0.408	<.001	3	view →
UCEC	All	III,IV	+0.281	.023	2	view →
LUAD	All	All	+0.108	.028	2	view →
LIHC	Male	All	+0.068	.013	2	view →
KIRC	All	III,IV	+0.058	.013	2	view →
COAD	Female	III,IV	−0.140	.040	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

HMGN2P23–HNSC

Open the HNSC breakdown →