HMGN1P8

Across TCGA pan-cancer cohorts, HMGN1P8 RNA is linked to patient survival in 20 of 34 cancer types, making it the most broadly survival-associated HMGN1P8 data layer.

The strongest signal is observed in uveal melanoma (UVM), where higher HMGN1P8 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated HMGN1P8 expression acts as an unfavorable survival marker, although some lineages such as UCEC and LUAD show a favorable association.

UVM, MESO, and UCEC are the cancer types where HMGN1P8 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Tertile	III,IV	0.223	0.639	.007	43	view →
MESO	OS	Quartile	III,IV	0.467	0.664	.009	32	view →
UCEC	DFS	Median	IV	0.855	0.509	.006	28	view →
PAAD	OS	Tertile	II,III,IV	0.229	0.482	.004	24	view →
THCA	DFS	Quartile	III,IV	0.795	0.956	.007	22	view →
BLCA	DFS	Quartile	II,III,IV	0.508	0.637	.004	16	view →
COAD	DFS	Median	All	0.617	0.745	.013	15	view →
CHOL	DFS	Median	IV	0.251	0.794	.010	12	view →
STAD	DFS	Tertile	IV	0.102	0.525	.031	12	view →
CESC	DFS	Quartile	III,IV	0.396	0.925	.017	12	view →
KIRP	DFS	Quartile	All	0.370	0.743	.004	11	view →
LUAD	OS	Tertile	All	0.858	0.717	.011	10	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

HMGN1P8–UVM (DFS)

Open the UVM breakdown →