HMGN1P7

Across TCGA pan-cancer cohorts, HMGN1P7 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of HMGN1P7’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where HMGN1P7 RNA is repressed in tumor relative to normal tissue. In most cancer types HMGN1P7 is over-expressed in tumor, although a few such as HNSC and KIRC show the opposite, repressed pattern.

HNSC, KIRC, and BRCA are the cancer types where HMGN1P7 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in HMGN1P7 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	II,III,IV	−0.510	<.001	7	view →
KIRC	All	II,III,IV	−0.166	<.001	7	view →
BRCA	All	III,IV	−0.566	<.001	6	view →
COAD	Female	All	−0.826	<.001	5	view →
LUAD	Male	III,IV	−0.629	.021	4	view →
LUSC	All	All	−0.355	.001	4	view →
KICH	All	All	−0.288	.005	4	view →
PRAD	All	All	+1.150	<.001	2	view →
CHOL	All	All	+0.386	.005	2	view →
UCEC	All	All	+0.366	.047	2	view →
KIRP	Male	All	−0.182	.010	2	view →
THCA	All	All	+0.152	.021	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

HMGN1P7–HNSC

Open the HNSC breakdown →