Across TCGA pan-cancer cohorts, HMGN1P32 RNA differs between tumor and matched normal tissue in 1 of 18 cancer types tested, making tumor–normal expression one of HMGN1P32’s most consistent transcriptional readouts.
The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where HMGN1P32 RNA is repressed in tumor relative to normal tissue. In most cancer types HMGN1P32 is over-expressed in tumor, although a few such as LIHC show the opposite, repressed pattern.
LIHC are the cancer types where HMGN1P32 tumor–normal differential expression is most reproducible.