HMGN1P14

Across TCGA pan-cancer cohorts, HMGN1P14 RNA differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of HMGN1P14’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where HMGN1P14 RNA is repressed in tumor relative to normal tissue. In most cancer types HMGN1P14 is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

THCA, KICH, and KIRC are the cancer types where HMGN1P14 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in HMGN1P14 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	All	All	−0.053	<.001	4	view →
KICH	All	II,III,IV	−0.074	.028	2	view →
KIRC	Female	All	+0.037	.020	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 3 strongest of 3 lineages.

HMGN1P14–THCA

Open the THCA breakdown →