HMGCS2

Across TCGA patient cohorts, HMGCS2 mutation is significantly associated with the RNA expression of many other genes, with 2,900 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HMGCS2-associated genes across cancer lineages are RNU6-433P, CENPI, and RNU6-642P. Each is linked with HMGCS2 in more than 2 cancer types. Because this analysis shows association rather than direction, both HMGCS2-to-partner and partner-to-HMGCS2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-433P grouped by HMGCS2-low versus HMGCS2-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HMGCS2→partner) and Y-score (partner→HMGCS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	RNU6-433P →	+0.591	+4.748	<.001	.003	3	3
UCEC	CENPI →	+0.503	+3.354	.004	.005	3	3
HNSC	RNU6-642P →	+0.358	+4.565	.005	.004	3	2
HNSC	RNU6-185P →	+0.225	+4.736	<.001	.007	3	2
CESC	TPT1P11 →	+0.147	+5.418	<.001	.005	3	2
UCEC	POLE2 →	+0.619	+1.947	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,900 associations by consensus.

RNU6-433P by HMGCS2 expression — HNSC

Explore this box plot interactively →