HMGCS1

Across TCGA pan-cancer cohorts, HMGCS1 mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated HMGCS1 data layer compared with 25 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher HMGCS1 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated HMGCS1 expression acts as an unfavorable survival marker.

CCRCC, LUAD, and OV are the cancer types where HMGCS1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	OS	Median	IV	0.123	0.785	.009	13	view →
LUAD	DFS	Median	All	0.465	0.777	<.001	10	view →
OV	DFS	Quartile	All	0.680	0.923	.035	8	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

HMGCS1–CCRCC (OS)

Open the CCRCC breakdown →