HMGCS1

Across TCGA patient cohorts, HMGCS1 RNA expression is significantly associated with the protein abundance of many other proteins, with 15,129 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible HMGCS1-associated proteins across cancer lineages are FDPS, HMGCS1_S4, and HMGCS1_S495. Each is linked with HMGCS1 in more than 8 cancer types. Because this analysis shows association rather than direction, both HMGCS1-to-partner and partner-to-HMGCS1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, HMGCS1 versus FDPS in HNSC, with a Pearson correlation of 0.41.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (HMGCS1→partner) and Y-score (partner→HMGCS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	FDPS →	+0.453	+0.904	<.001	<.001	3	9
LSCC	HMGCS1_S4 →	+1.366	+1.236	<.001	<.001	3	8
LUAD	HMGCS1_S495 →	+1.351	+0.814	<.001	<.001	3	7
HNSC	FDFT1 →	+0.711	+0.780	<.001	<.001	3	7
LSCC	KIAA1671 →	+0.389	+0.969	<.001	<.001	3	6
PDAC	MVD →	+0.331	+0.664	<.001	<.001	2	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 15,129 associations by consensus.

HMGCS1 vs FDPS — HNSC

Explore this scatter interactively →