HMGCS1

Across TCGA patient cohorts, HMGCS1 mutation is significantly associated with the total protein of many other genes, with 22 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HMGCS1-associated genes across cancer lineages are Bad_pS112, 4E-BP1_pT37_T46, and HER2. Each is linked with HMGCS1 in more than 1 cancer types. Because this analysis shows association rather than direction, both HMGCS1-to-partner and partner-to-HMGCS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Bad_pS112 grouped by HMGCS1-low versus HMGCS1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HMGCS1→partner) and Y-score (partner→HMGCS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Bad_pS112 →	-0.212	-2.584	.002	.010	3	2
UCEC	4E-BP1_pT37_T46 →	-0.369	-2.115	.010	.017	3	2
UCEC	HER2 →	-0.414	-3.321	.017	.009	3	1
UCEC	HER3_pY1289 →	+0.079	+1.704	.017	.013	3	1
UCEC	IGFBP2 →	-0.629	-1.678	.011	.023	3	1
UCEC	MEK1 →	+0.408	+2.584	.003	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

Bad_pS112 by HMGCS1 expression — UCEC

Explore this box plot interactively →