HMGCS1

Across TCGA cell cohorts, HMGCS1 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,270 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible HMGCS1-associated GO terms across cancer lineages are Secondary alcohol biosynthetic process, Cholesterol biosynthetic process via desmosterol, and Cholesterol biosynthetic process via lathosterol. Each is linked with HMGCS1 in more than 19 cancer types. Because this analysis shows association rather than direction, both HMGCS1-to-partner and partner-to-HMGCS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Secondary alcohol biosynthetic process grouped by HMGCS1-low versus HMGCS1-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (HMGCS1→partner) and Y-score (partner→HMGCS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Secondary alcohol biosynthetic process →	+0.214	+1.834	<.001	<.001	3	20
OESOPHAGUS	Cholesterol biosynthetic process via desmosterol →	+0.247	+2.407	<.001	<.001	3	20
BONE	Cholesterol biosynthetic process via lathosterol →	+0.228	+1.671	<.001	<.001	3	20
BONE	Zymosterol metabolic process →	+0.238	+1.743	<.001	<.001	3	20
BONE	Zymosterol biosynthetic process →	+0.238	+1.743	<.001	<.001	3	20
BONE	Cholesterol biosynthetic process →	+0.214	+1.834	<.001	<.001	3	20

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,270 associations by consensus.

Secondary alcohol biosynthetic process by HMGCS1 expression — BONE

Explore this box plot interactively →