HMGCS1

Across TCGA cell cohorts, HMGCS1 mutation is significantly associated with the RNA expression of many other genes, with 18 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible HMGCS1-associated genes across cancer lineages are MAGEB4, SAXO1, and CFAP161. Each is linked with HMGCS1 in more than 1 cancer types. Because this analysis shows association rather than direction, both HMGCS1-to-partner and partner-to-HMGCS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MAGEB4 grouped by HMGCS1-low versus HMGCS1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HMGCS1→partner) and Y-score (partner→HMGCS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	MAGEB4 →	+0.012	+3.678	<.001	.001	3	1
LARGE_INTESTINE	SAXO1 →	+0.035	+3.819	.007	.001	3	1
LARGE_INTESTINE	CFAP161 →	+0.220	+3.281	.005	.005	3	1
LARGE_INTESTINE	CMKLR1 →	+0.116	+3.830	.004	.003	3	1
LARGE_INTESTINE	TFDP3 →	+0.015	+2.933	.004	.003	3	1
LARGE_INTESTINE	TAFA1 →	+0.209	+2.688	.003	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

MAGEB4 by HMGCS1 expression — LARGE_INTESTINE

Explore this box plot interactively →