HMGCR

Across TCGA pan-cancer cohorts, HMGCR Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated HMGCR data layer compared with 26 for mass-spec protein and 5 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher HMGCR Mutation is associated with better disease-free survival. In most high-consensus cancer types, elevated HMGCR expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

UCEC, HNSC, and ESCA are the cancer types where HMGCR Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	II,III,IV	1.000	0.426	.002	34	view →
HNSC	OS	Median	All	0.156	0.710	.002	24	view →
ESCA	OS	Median	All	0.095	0.701	<.001	12	view →
LIHC	DFS	Median	All	0.157	0.545	.012	6	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

HMGCR–UCEC (DFS)

Open the UCEC breakdown →