HMGCR

Across TCGA pan-cancer cohorts, HMGCR RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of HMGCR’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where HMGCR RNA is repressed in tumor relative to normal tissue. In most cancer types HMGCR is over-expressed in tumor, although a few such as KIRC and THCA show the opposite, repressed pattern.

KIRC, THCA, and BLCA are the cancer types where HMGCR tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in HMGCR RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	III,IV	−0.777	<.001	11	view →
THCA	Male	III,IV	−1.288	<.001	10	view →
BLCA	Male	III,IV	+1.700	<.001	8	view →
LUAD	Female	All	−0.647	<.001	7	view →
UCEC	All	All	+1.108	<.001	6	view →
KIRP	Male	All	−1.067	<.001	6	view →
BRCA	All	III,IV	+0.887	<.001	6	view →
LIHC	Male	All	+0.912	<.001	5	view →
READ	All	III,IV	+0.895	.030	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

HMGCR–KIRC

Open the KIRC breakdown →