HMGCR

Across TCGA pan-cancer cohorts, HMGCR mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated HMGCR data layer compared with 26 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher HMGCR mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated HMGCR expression acts as an unfavorable survival marker, although some lineages such as UCEC and PDAC show a favorable association.

LUAD, UCEC, and PDAC are the cancer types where HMGCR mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Median	III,IV	0.372	0.869	.016	10	view →
UCEC	DFS	Median	All	1.000	0.936	.021	6	view →
PDAC	OS	Median	III,IV	1.000	0.647	.049	3	view →
GBM	OS	Median	All	0.545	0.287	.030	3	view →
LSCC	DFS	Quartile	III,IV	1.000	0.490	.049	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

HMGCR–LUAD (OS)

Open the LUAD breakdown →