HMGCR

Across TCGA patient cohorts, HMGCR RNA expression is significantly associated with the protein abundance of many other proteins, with 18,327 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible HMGCR-associated proteins across cancer lineages are FDFT1, FDPS, and HMGCS1. Each is linked with HMGCR in more than 7 cancer types. Because this analysis shows association rather than direction, both HMGCR-to-partner and partner-to-HMGCR results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, HMGCR versus FDFT1 in HNSC, with a Pearson correlation of 0.35.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (HMGCR→partner) and Y-score (partner→HMGCR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	FDFT1 →	+0.812	+0.875	<.001	<.001	3	7
HNSC	FDPS →	+0.432	+0.635	<.001	.003	2	8
HNSC	HMGCS1 →	+0.904	+0.980	<.001	<.001	3	6
HNSC	IDI1 →	+0.603	+1.177	<.001	<.001	3	6
HNSC	MVK →	+0.528	+0.668	<.001	.008	3	5
UCEC	CERT1 →	+0.336	+0.817	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 18,327 associations by consensus.

HMGCR vs FDFT1 — HNSC

Explore this scatter interactively →