HMGCR

Across TCGA patient cohorts, HMGCR protein abundance is significantly associated with the RNA expression of many other genes, with 5,212 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible HMGCR-associated genes across cancer lineages are LGALSL, EFEMP1, and STAG1. Each is linked with HMGCR in more than 2 cancer types. Because this analysis shows association rather than direction, both HMGCR-to-partner and partner-to-HMGCR results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, HMGCR versus LGALSL in LSCC, with a Pearson correlation of 0.39.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HMGCR→partner) and Y-score (partner→HMGCR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	LGALSL →	+0.985	+0.651	<.001	<.001	3	3
OV	EFEMP1 →	-1.616	-0.558	.004	.006	3	2
OV	STAG1 →	-0.644	-0.530	<.001	.008	3	2
OV	PLVAP →	-1.021	-0.409	.004	.008	3	2
OV	LCP1 →	-1.163	-0.470	.001	.009	3	2
OV	MYO1G →	-0.537	-0.588	.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,212 associations by consensus.

HMGCR vs LGALSL — LSCC

Explore this scatter interactively →