HMGCR

Across TCGA patient cohorts, HMGCR mutation is significantly associated with the total protein of many other genes, with 63 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HMGCR-associated genes across cancer lineages are Caspase-7-cleavedD198, EGFR_pY1068, and INPP4B. Each is linked with HMGCR in more than 2 cancer types. Because this analysis shows association rather than direction, both HMGCR-to-partner and partner-to-HMGCR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by HMGCR-low versus HMGCR-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HMGCR→partner) and Y-score (partner→HMGCR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.476	+1.756	.006	.003	3	3
UCEC	EGFR_pY1068 →	-0.268	-1.637	<.001	.001	3	2
UCEC	INPP4B →	-0.214	-1.847	.024	.007	3	2
UCEC	Ku80 →	+0.246	+1.650	<.001	<.001	3	2
UCEC	MEK1 →	+0.450	+1.857	<.001	<.001	3	2
UCEC	P-Cadherin →	-0.135	-2.502	.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 63 associations by consensus.

Caspase-7-cleavedD198 by HMGCR expression — UCEC

Explore this box plot interactively →