HMGCR

Across TCGA cell cohorts, HMGCR RNA expression is significantly associated with the go_rna of many other GO terms, with 3,880 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible HMGCR-associated GO terms across cancer lineages are Isopentenyl diphosphate biosynthetic process, Cholesterol biosynthetic process via desmosterol, and Isopentenyl diphosphate metabolic process. Each is linked with HMGCR in more than 19 cancer types. Because this analysis shows association rather than direction, both HMGCR-to-partner and partner-to-HMGCR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Isopentenyl diphosphate biosynthetic process grouped by HMGCR-low versus HMGCR-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (HMGCR→partner) and Y-score (partner→HMGCR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Isopentenyl diphosphate biosynthetic process →	+0.186	+1.484	<.001	<.001	3	20
BONE	Cholesterol biosynthetic process via desmosterol →	+0.226	+1.369	<.001	<.001	3	20
BONE	Isopentenyl diphosphate metabolic process →	+0.186	+1.484	<.001	<.001	3	20
BONE	Farnesyl diphosphate biosynthetic process, mevalonate pathway →	+0.196	+1.435	<.001	<.001	3	19
OESOPHAGUS	Sterol biosynthetic process →	+0.210	+1.793	<.001	<.001	3	19
OESOPHAGUS	Secondary alcohol biosynthetic process →	+0.220	+1.718	<.001	.001	3	19

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,880 associations by consensus.

Isopentenyl diphosphate biosynthetic process by HMGCR expression — BONE

Explore this box plot interactively →