HMGCR

Across TCGA cell cohorts, HMGCR mutation is significantly associated with the RNA expression of many other genes, with 122 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible HMGCR-associated genes across cancer lineages are HMGB4, JOSD1, and MIOX. Each is linked with HMGCR in more than 1 cancer types. Because this analysis shows association rather than direction, both HMGCR-to-partner and partner-to-HMGCR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HMGB4 grouped by HMGCR-low versus HMGCR-high in OESOPHAGUS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HMGCR→partner) and Y-score (partner→HMGCR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	HMGB4 →	+0.043	+4.906	<.001	.006	3	1
LARGE_INTESTINE	JOSD1 →	+0.628	+3.212	.001	.006	3	1
LARGE_INTESTINE	MIOX →	+0.266	+3.241	.003	.007	3	1
LARGE_INTESTINE	ACBD5 →	+0.916	+3.212	<.001	.006	3	1
LARGE_INTESTINE	PRDM4 →	+0.480	+3.299	.005	.004	3	1
LARGE_INTESTINE	HINT3 →	+0.929	+3.212	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 122 associations by consensus.

HMGB4 by HMGCR expression — OESOPHAGUS

Explore this box plot interactively →