HMGCLL1

Across TCGA patient cohorts, HMGCLL1 mutation is significantly associated with the total protein of many other genes, with 43 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HMGCLL1-associated genes across cancer lineages are ACC1, JNK2, and ASNS. Each is linked with HMGCLL1 in more than 1 cancer types. Because this analysis shows association rather than direction, both HMGCLL1-to-partner and partner-to-HMGCLL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ACC1 grouped by HMGCLL1-low versus HMGCLL1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HMGCLL1→partner) and Y-score (partner→HMGCLL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ACC1 →	+0.249	+1.713	.035	.024	3	2
UCEC	JNK2 →	+0.207	+2.611	.001	.005	3	2
UCEC	ASNS →	+0.377	+1.906	.001	.014	3	2
UCEC	ATM →	-0.502	-2.000	<.001	<.001	3	2
UCEC	BRCA2 →	-0.104	-2.416	.012	.018	3	2
UCEC	Caspase-7-cleavedD198 →	+0.536	+1.522	.005	.017	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 43 associations by consensus.

ACC1 by HMGCLL1 expression — UCEC

Explore this box plot interactively →