HMGCL

Across TCGA patient cohorts, HMGCL protein abundance is significantly associated with the RNA expression of many other genes, with 15,030 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible HMGCL-associated genes across cancer lineages are SDC4, FANCI, and CCNB2. Each is linked with HMGCL in more than 6 cancer types. Because this analysis shows association rather than direction, both HMGCL-to-partner and partner-to-HMGCL results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, HMGCL versus SDC4 in GBM, with a Pearson correlation of 0.49.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HMGCL→partner) and Y-score (partner→HMGCL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SDC4 →	+0.852	+0.324	<.001	<.001	3	6
GBM	FANCI →	-0.835	-0.360	<.001	<.001	3	6
BRCA	CCNB2 →	-1.050	-0.400	<.001	<.001	3	6
BRCA	CDCA2 →	-1.004	-0.343	<.001	<.001	3	6
BRCA	CDC45 →	-0.965	-0.452	<.001	<.001	3	6
LSCC	HELLS →	-0.678	-0.206	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 15,030 associations by consensus.

HMGCL vs SDC4 — GBM

Explore this scatter interactively →