HMGCL

Across TCGA patient cohorts, HMGCL mutation is significantly associated with the RNA expression of many other genes, with 179 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HMGCL-associated genes across cancer lineages are MIR5787, RNU6-1214P, and MIR1305. Each is linked with HMGCL in more than 1 cancer types. Because this analysis shows association rather than direction, both HMGCL-to-partner and partner-to-HMGCL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR5787 grouped by HMGCL-low versus HMGCL-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HMGCL→partner) and Y-score (partner→HMGCL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	MIR5787 →	+0.604	+4.513	<.001	.001	3	2
CESC	RNU6-1214P →	+0.368	+5.306	<.001	.006	3	1
CESC	MIR1305 →	+0.454	+5.812	<.001	.003	3	1
CESC	SNX18P8 →	+0.056	+5.812	<.001	.003	3	1
CESC	TET1P1 →	+0.032	+5.812	<.001	.003	3	1
SKCM	GAGE13 →	+0.428	+3.449	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 179 associations by consensus.

MIR5787 by HMGCL expression — SKCM

Explore this box plot interactively →