HMGCL

Across TCGA patient cohorts, HMGCL mutation is significantly associated with the total protein of many other genes, with 8 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HMGCL-associated genes across cancer lineages are IGFBP2, MEK1, and MSH2. Each is linked with HMGCL in more than 1 cancer types. Because this analysis shows association rather than direction, both HMGCL-to-partner and partner-to-HMGCL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IGFBP2 grouped by HMGCL-low versus HMGCL-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HMGCL→partner) and Y-score (partner→HMGCL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	IGFBP2 →	-1.031	-3.169	<.001	.018	3	1
UCEC	MEK1 →	+0.484	+3.169	.006	.019	3	1
UCEC	MSH2 →	-0.283	-2.973	.011	.035	3	1
UCEC	PCNA →	+0.241	+2.459	.020	.020	3	1
UCEC	Chk2 →	-0.349	-3.459	.002	.005	3	1
UCEC	ATM →	-0.689	-2.459	.001	.020	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

IGFBP2 by HMGCL expression — UCEC

Explore this box plot interactively →