HMGCL

Across TCGA cell cohorts, HMGCL RNA expression is significantly associated with the go_rna of many other GO terms, with 3,716 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible HMGCL-associated GO terms across cancer lineages are Maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), Process utilizing autophagic mechanism, and Transcription elongation by RNA polymerase I. Each is linked with HMGCL in more than 13 cancer types. Because this analysis shows association rather than direction, both HMGCL-to-partner and partner-to-HMGCL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) grouped by HMGCL-low versus HMGCL-high in OESOPHAGUS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (HMGCL→partner) and Y-score (partner→HMGCL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	Maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) →	-0.141	-1.275	.004	.006	3	13
KIDNEY	Process utilizing autophagic mechanism →	+0.058	+0.820	<.001	.003	2	14
BLOOD_Myeloma	Transcription elongation by RNA polymerase I →	-0.124	-0.848	<.001	.004	3	13
KIDNEY	Autophagy →	+0.058	+0.820	<.001	.003	2	14
STOMACH	L-leucine metabolic process →	+0.183	+1.143	<.001	<.001	3	12
STOMACH	L-leucine catabolic process →	+0.183	+1.143	<.001	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,716 associations by consensus.

Maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) by HMGCL expression — OESOPHAGUS

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