HMGB4

Across TCGA patient cohorts, HMGB4 RNA expression is significantly associated with the protein abundance of many other proteins, with 9,251 significant associations in total. GBM shows the largest number of these associations.

The most reproducible HMGB4-associated proteins across cancer lineages are RCN3, RUNX2_S28, and SERPINH1. Each is linked with HMGB4 in more than 3 cancer types. Because this analysis shows association rather than direction, both HMGB4-to-partner and partner-to-HMGB4 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, HMGB4 versus RCN3 in HNSC, with a Pearson correlation of 0.32.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (HMGB4→partner) and Y-score (partner→HMGB4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	RCN3 →	+0.442	+0.325	.001	.003	3	4
LSCC	RUNX2_S28 →	+0.808	+0.215	<.001	<.001	3	4
HNSC	SERPINH1 →	+0.403	+0.336	.002	.004	3	4
LSCC	SFRP2 →	+0.702	+0.152	<.001	.003	3	4
LUAD	CCDC80 →	+0.646	+0.214	<.001	.001	3	4
LUAD	CEP170 →	+0.178	+0.171	.003	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 9,251 associations by consensus.

HMGB4 vs RCN3 — HNSC

Explore this scatter interactively →