HMGB4

RNA — tumor vs normal
Tumor vs NormalRNABox plot · TCGA cohorts

Across TCGA pan-cancer cohorts, HMGB4 RNA differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of HMGB4’s most consistent transcriptional readouts.

The strongest signal is observed in breast invasive carcinoma (BRCA), where HMGB4 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types HMGB4 is over-expressed in tumor.

BRCA and LUAD are the cancer types where HMGB4 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in HMGB4 RNA (log2); positive values indicate higher expression in tumor. p-values are from the differential-expression test.
LineageGenderStageFold-changepSampling consensus
BRCAAllAll+0.014.0234view →
LUADAllAll+0.016.0351view →
Pink = over-expressed in tumor, green = repressed in tumor. Showing the 2 strongest of 2 lineages.

HMGB4–BRCA

Tumor-vs-normal expression box plot for HMGB4 RNA in BRCA.

Open the BRCA breakdown →

Exploration