HMGB4

Across TCGA patient cohorts, HMGB4 mutation is significantly associated with the total protein of many other genes, with 8 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HMGB4-associated genes across cancer lineages are p27_pT198, Caveolin-1, and p53. Each is linked with HMGB4 in more than 1 cancer types. Because this analysis shows association rather than direction, both HMGB4-to-partner and partner-to-HMGB4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p27_pT198 grouped by HMGB4-low versus HMGB4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HMGB4→partner) and Y-score (partner→HMGB4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p27_pT198 →	+0.135	+3.000	.029	.037	3	1
UCEC	Caveolin-1 →	-1.094	-3.000	.009	.037	3	1
SKCM	p53 →	+0.259	+1.891	.002	.030	3	1
UCEC	PKC-a_pS657 →	-0.500	-2.986	.023	.037	2	1
SKCM	CDK1 →	+0.177	+3.169	.027	.018	2	1
UCEC	Acetyl-a-Tubulin-Lys40 →	+0.740	+3.000	.011	.037	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

p27_pT198 by HMGB4 expression — UCEC

Explore this box plot interactively →