HMGB4

Across TCGA cell cohorts, HMGB4 RNA expression is significantly associated with the mutation status of many other genes, with 62 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible HMGB4-associated genes across cancer lineages are EPHA3, SH3BP1, and AMOTL2. Each is linked with HMGB4 in more than 1 cancer types. Because this analysis shows association rather than direction, both HMGB4-to-partner and partner-to-HMGB4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EPHA3 grouped by HMGB4-low versus HMGB4-high in OESOPHAGUS.

RNA expression associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HMGB4→partner) and Y-score (partner→HMGB4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	EPHA3 →	+4.906	+0.043	.006	<.001	3	2
PANCREAS	SH3BP1 →	+5.000	+0.022	.006	<.001	3	1
PANCREAS	AMOTL2 →	+5.000	+0.022	.006	<.001	3	1
PANCREAS	PRR12 →	+4.000	+0.018	<.001	<.001	3	1
PANCREAS	PARP1 →	+5.000	+0.033	.006	<.001	3	1
PANCREAS	CNTNAP3B →	+5.000	+0.015	.006	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 62 associations by consensus.

EPHA3 by HMGB4 expression — OESOPHAGUS

Explore this box plot interactively →