HMGB4

Across TCGA cell cohorts, HMGB4 mutation is significantly associated with the RNA expression of many other genes, with 9 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible HMGB4-associated genes across cancer lineages are OR1L6, OR13C8, and ZNF735. Each is linked with HMGB4 in more than 1 cancer types. Because this analysis shows association rather than direction, both HMGB4-to-partner and partner-to-HMGB4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR1L6 grouped by HMGB4-low versus HMGB4-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HMGB4→partner) and Y-score (partner→HMGB4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	OR1L6 →	+0.014	+4.662	<.001	.005	3	1
LUNG_NSCLC_LUAD	OR13C8 →	+0.024	+4.662	<.001	.005	3	1
LUNG_NSCLC_LUAD	ZNF735 →	+0.034	+4.947	<.001	.001	3	1
LUNG_NSCLC_LUAD	GYPB →	+0.095	+4.544	<.001	.003	3	1
LARGE_INTESTINE	PRG3 →	+0.021	+4.415	<.001	.007	3	1
LARGE_INTESTINE	P2RY12 →	+0.114	+4.273	.009	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

OR1L6 by HMGB4 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →