HMGB3P9

Across TCGA pan-cancer cohorts, HMGB3P9 RNA is linked to patient survival in 16 of 34 cancer types, making it the most broadly survival-associated HMGB3P9 data layer.

The strongest signal is observed in pancreatic adenocarcinoma (PAAD), where higher HMGB3P9 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated HMGB3P9 expression acts as an unfavorable survival marker, although some lineages such as CHOL and STAD show a favorable association.

PAAD, KICH, and KIRC are the cancer types where HMGB3P9 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PAAD	DFS	Quartile	All	0.196	0.473	.004	51	view →
KICH	OS	Quartile	III,IV	0.178	0.891	<.001	37	view →
KIRC	DFS	Tertile	All	0.505	0.712	<.001	30	view →
UCEC	DFS	Tertile	II,III,IV	0.635	0.773	.017	24	view →
READ	DFS	Tertile	IV	0.112	0.811	.008	17	view →
COAD	DFS	Tertile	II,III,IV	0.500	0.678	.030	15	view →
LGG	DFS	Median	All	0.772	0.881	.001	12	view →
CHOL	DFS	Tertile	All	1.000	0.289	.032	9	view →
HNSC	DFS	Tertile	IV	0.490	0.620	.043	8	view →
LIHC	DFS	Tertile	All	0.447	0.580	.027	6	view →
SKCM	OS	Median	IV	0.140	0.621	.044	3	view →
STAD	OS	Median	IV	0.690	0.328	.039	3	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 16 lineages.

HMGB3P9–PAAD (DFS)

Open the PAAD breakdown →