HMGB3P9

Across TCGA pan-cancer cohorts, HMGB3P9 RNA differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of HMGB3P9’s most consistent transcriptional readouts.

The strongest signal is observed in pancreatic adenocarcinoma (PAAD), where HMGB3P9 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types HMGB3P9 is over-expressed in tumor, although a few such as THCA show the opposite, repressed pattern.

PAAD, BLCA, and THCA are the cancer types where HMGB3P9 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in HMGB3P9 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
PAAD	Female	All	+0.380	.038	2	view →
BLCA	Female	All	+0.196	.022	2	view →
THCA	All	II,III,IV	−0.110	.007	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 3 strongest of 3 lineages.

HMGB3P9–PAAD

Open the PAAD breakdown →