HMGB3P27

Across TCGA pan-cancer cohorts, HMGB3P27 RNA is linked to patient survival in 15 of 34 cancer types, making it the most broadly survival-associated HMGB3P27 data layer.

The strongest signal is observed in lymphoid neoplasm diffuse large b-cell lymphoma (DLBC), where higher HMGB3P27 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated HMGB3P27 expression acts as an unfavorable survival marker, although some lineages such as BLCA and OV show a favorable association.

DLBC, BLCA, and SKCM are the cancer types where HMGB3P27 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
DLBC	DFS	Tertile	All	0.338	0.795	.010	76	view →
BLCA	DFS	Tertile	All	0.432	0.302	.010	64	view →
SKCM	DFS	Tertile	IV	0.036	0.433	<.001	48	view →
KIRC	DFS	Tertile	IV	0.384	0.684	.015	48	view →
BRCA	OS	Tertile	II,III,IV	0.849	0.919	.016	36	view →
KIRP	OS	Tertile	All	0.460	0.724	.002	24	view →
COAD	OS	Tertile	All	0.597	0.817	.011	21	view →
UCS	OS	Tertile	II,III,IV	0.212	0.557	.028	18	view →
OV	OS	Tertile	II,III,IV	0.743	0.672	.040	16	view →
KICH	OS	Tertile	II,III,IV	0.612	1.000	.009	13	view →
LUSC	OS	Quartile	II,III,IV	0.641	0.342	.002	10	view →
PAAD	OS	Tertile	All	0.258	0.494	.029	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 15 lineages.

HMGB3P27–DLBC (DFS)

Open the DLBC breakdown →