HMGB3P27

Across TCGA pan-cancer cohorts, HMGB3P27 RNA differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of HMGB3P27’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where HMGB3P27 RNA is repressed in tumor relative to normal tissue. In most cancer types HMGB3P27 is over-expressed in tumor, although a few such as KIRC and ESCA show the opposite, repressed pattern.

KIRC, KICH, and LUAD are the cancer types where HMGB3P27 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in HMGB3P27 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	All	III,IV	−0.056	<.001	11	view →
KICH	All	All	+0.286	.012	4	view →
LUAD	All	All	+0.071	.002	4	view →
ESCA	All	All	−1.138	.012	2	view →
LUSC	All	All	+0.053	.008	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

HMGB3P27–KIRC

Open the KIRC breakdown →