Q-omics provides the consensus-scored HMGB3P18 profile across patient tissues and cancer cell-line models. HMGB3P18 expression is associated with patient survival in 11 of 34 cancer types, with the highest sampling consensus in HNSC. Additionally, HMGB3P18 RNA expression shows 6,338 significant pathway-activity associations, with the highest sampling consensus in STAD. Together, these results highlight HNSC, and STAD as cancer lineages where HMGB3P18 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.

Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.

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Survival associations

This table summarizes HMGB3P18 survival associations across molecular data types. HMGB3P18 RNA expression shows survival associations in the most cancer types (11). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.

HMGB3P18 data type	Survival analysis	Lineage consensus	Lineage of highest sampling consensus
RNA	Kaplan–Meier	11	HNSC (96)	view →

This table ranks reproducible HMGB3P18 RNA expression–survival associations across cancer types. High HMGB3P18 expression shows unfavorable associations in HNSC, KICH, PAAD, STAD and COAD, but favorable associations in LUSC. The HNSC Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify HNSC as the clearest survival context for HMGB3P18 RNA expression.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Tertile	III,IV	0.281	0.694	<.001	96	view →
KICH	DFS	Tertile	All	0.081	0.904	<.001	90	view →
PAAD	OS	Tertile	All	0.037	0.641	<.001	36	view →
STAD	OS	Tertile	IV	0.133	0.520	.003	36	view →
COAD	OS	Tertile	IV	0.039	0.660	<.001	36	view →
LUSC	OS	Tertile	All	0.489	0.362	.014	30	view →

Pink = unfavorable, green = favorable. all 11 lineages →

HMGB3P18-HNSC (OS)

Kaplan–Meier survival curve for HMGB3P18 RNA expression in HNSC: high vs low expression groups.

Explore this curve interactively →

Cross-omics associations

This table shows molecular features associated with HMGB3P18 in patient tissues and cancer cell lines. In patient samples, HMGB3P18 shows the broadest associations at the RNA and protein expression levels, with STAD recurring as the lineage with the largest associated feature set.

Associated data type	Strength (# associated data)	Lineage of highest associated data
▼RNA
Function (RNA)	6,338	STAD (5739)	view →
Protein (mass-spec)	5,143	CCRCC (2438)	view →