HMGB3P14

Across TCGA pan-cancer cohorts, HMGB3P14 RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated HMGB3P14 data layer.

The strongest signal is observed in uveal melanoma (UVM), where higher HMGB3P14 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated HMGB3P14 expression acts as an unfavorable survival marker, although some lineages such as KIRC and ACC show a favorable association.

UVM, CESC, and KIRC are the cancer types where HMGB3P14 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Tertile	III,IV	0.192	0.627	<.001	62	view →
CESC	DFS	Quartile	II,III,IV	0.198	0.687	.001	52	view →
KIRC	DFS	Median	II,III,IV	0.861	0.739	.001	41	view →
ACC	OS	Median	All	0.925	0.467	.003	36	view →
SARC	OS	Quartile	All	0.404	0.680	.003	19	view →
KICH	DFS	Median	II,III,IV	0.422	0.928	.009	17	view →
STAD	DFS	Quartile	III,IV	0.298	0.548	.007	16	view →
BLCA	DFS	Tertile	IV	0.234	0.543	.003	13	view →
LIHC	DFS	Tertile	II,III,IV	0.262	0.457	.019	9	view →
KIRP	DFS	Median	III,IV	0.775	0.432	.011	9	view →
SKCM	DFS	Tertile	IV	0.111	0.694	.004	9	view →
UCS	OS	Median	III,IV	0.542	0.233	.044	8	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

HMGB3P14–UVM (DFS)

Open the UVM breakdown →