HMGB3P14

Across TCGA pan-cancer cohorts, HMGB3P14 RNA differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of HMGB3P14’s most consistent transcriptional readouts.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where HMGB3P14 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types HMGB3P14 is over-expressed in tumor, although a few such as BRCA and KIRP show the opposite, repressed pattern.

BLCA, HNSC, and BRCA are the cancer types where HMGB3P14 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in HMGB3P14 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BLCA	Female	All	+0.141	.012	4	view →
HNSC	Male	All	+0.127	.001	4	view →
BRCA	All	III,IV	−0.246	.012	2	view →
PAAD	Male	All	+0.200	.021	2	view →
KIRP	Male	All	−0.085	.038	1	view →
LIHC	All	All	+0.024	.024	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

HMGB3P14–BLCA

Open the BLCA breakdown →