HMGB3

Across TCGA patient cohorts, HMGB3 RNA expression is significantly associated with the protein abundance of many other proteins, with 19,722 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible HMGB3-associated proteins across cancer lineages are KPNA2, MCM3, and MCM5. Each is linked with HMGB3 in more than 8 cancer types. Because this analysis shows association rather than direction, both HMGB3-to-partner and partner-to-HMGB3 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, HMGB3 versus KPNA2 in OV, with a Pearson correlation of 0.33.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (HMGB3→partner) and Y-score (partner→HMGB3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	KPNA2 →	+0.593	+0.701	.001	.001	3	9
LUAD	MCM3 →	+0.574	+1.122	<.001	.002	3	9
BRCA	MCM5 →	+0.693	+1.112	<.001	<.001	3	9
OV	MCM6 →	+0.689	+1.060	<.001	<.001	3	9
OV	MCM7 →	+0.680	+0.794	<.001	.001	3	9
GBM	NCAPD2 →	+0.634	+0.815	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 19,722 associations by consensus.

HMGB3 vs KPNA2 — OV

Explore this scatter interactively →