HMGB2

Across TCGA patient cohorts, HMGB2 protein abundance is significantly associated with the RNA expression of many other genes, with 12,585 significant associations in total. GBM shows the largest number of these associations.

The most reproducible HMGB2-associated genes across cancer lineages are LMNB1, EXO1, and MCM3. Each is linked with HMGB2 in more than 8 cancer types. Because this analysis shows association rather than direction, both HMGB2-to-partner and partner-to-HMGB2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, HMGB2 versus LMNB1 in UCEC, with a Pearson correlation of 0.58.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HMGB2→partner) and Y-score (partner→HMGB2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	LMNB1 →	+1.015	+0.409	<.001	<.001	3	9
LUAD	EXO1 →	+1.048	+0.266	<.001	<.001	3	9
HNSC	MCM3 →	+0.894	+0.509	<.001	<.001	3	8
BRCA	KIF20A →	+1.252	+0.591	<.001	<.001	3	8
UCEC	CDCA8 →	+1.008	+0.350	<.001	<.001	3	8
BRCA	TCF19 →	+1.029	+0.562	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 12,585 associations by consensus.

HMGB2 vs LMNB1 — UCEC

Explore this scatter interactively →