Across TCGA pan-cancer cohorts, HMGB1P9 RNA differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of HMGB1P9’s most consistent transcriptional readouts.

The strongest signal is observed in breast invasive carcinoma (BRCA), where HMGB1P9 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types HMGB1P9 is over-expressed in tumor, although a few such as THCA show the opposite, repressed pattern.

BRCA, STAD, and HNSC are the cancer types where HMGB1P9 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in HMGB1P9 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BRCA	All	All	+0.025	.043	2	view →
STAD	All	All	+0.115	.022	1	view →
HNSC	Male	All	+0.085	.041	1	view →
THCA	Male	All	−0.069	.022	1	view →
LUSC	All	All	+0.036	.046	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

Exploration

Same gene, other analysis: HMGB1P9 RNA expression & survival · all HMGB1P9 data types