HMGB1P44

Across TCGA pan-cancer cohorts, HMGB1P44 RNA differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of HMGB1P44’s most consistent transcriptional readouts.

The strongest signal is observed in breast invasive carcinoma (BRCA), where HMGB1P44 RNA is repressed in tumor relative to normal tissue. In most cancer types HMGB1P44 is over-expressed in tumor, although a few such as BRCA and BLCA show the opposite, repressed pattern.

BRCA, HNSC, and BLCA are the cancer types where HMGB1P44 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in HMGB1P44 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BRCA	All	All	−0.053	.002	6	view →
HNSC	All	II,III,IV	+0.085	.031	3	view →
BLCA	Male	All	−0.073	.033	3	view →
KIRP	All	All	−0.045	.033	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

HMGB1P44–BRCA

Open the BRCA breakdown →