HMGB1P33

Across TCGA patient cohorts, HMGB1P33 RNA expression is significantly associated with the go_rna of many other GO terms, with 6,010 significant associations in total. STAD shows the largest number of these associations.

The most reproducible HMGB1P33-associated GO terms across cancer lineages are Transcription by RNA polymerase III, Positive regulation of protein modification by small protein conjugation or removal, and Regulation of translational initiation. Each is linked with HMGB1P33 in more than 14 cancer types. Because this analysis shows association rather than direction, both HMGB1P33-to-partner and partner-to-HMGB1P33 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Transcription by RNA polymerase III grouped by HMGB1P33-low versus HMGB1P33-high in STAD.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (HMGB1P33→partner) and Y-score (partner→HMGB1P33) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	Transcription by RNA polymerase III →	+0.053	+0.140	<.001	<.001	3	14
STAD	Positive regulation of protein modification by small protein conjugation or removal →	+0.039	+0.066	<.001	<.001	3	13
LAML	Regulation of translational initiation →	+0.053	+0.283	<.001	.001	3	13
STAD	Protein K63-linked ubiquitination →	+0.043	+0.080	<.001	<.001	3	13
STAD	Protein polymerization →	+0.035	+0.067	<.001	<.001	3	13
STAD	Protein K48-linked ubiquitination →	+0.047	+0.076	<.001	<.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,010 associations by consensus.

Transcription by RNA polymerase III by HMGB1P33 expression — STAD

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