HMGB1P33

Across TCGA pan-cancer cohorts, HMGB1P33 RNA is linked to patient survival in 17 of 34 cancer types, making it the most broadly survival-associated HMGB1P33 data layer.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher HMGB1P33 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated HMGB1P33 expression acts as an unfavorable survival marker, although some lineages such as COAD and ESCA show a favorable association.

KIRC, TGCT, and KICH are the cancer types where HMGB1P33 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Tertile	II,III,IV	0.551	0.771	<.001	132	view →
TGCT	DFS	Tertile	II,III,IV	0.045	0.955	<.001	90	view →
KICH	DFS	Tertile	II,III,IV	0.025	0.860	<.001	45	view →
UCEC	OS	Tertile	All	0.326	0.712	.005	36	view →
READ	DFS	Tertile	IV	0.514	0.636	.008	33	view →
ACC	OS	Tertile	All	0.243	0.734	.018	15	view →
KIRP	OS	Tertile	II,III,IV	0.124	0.588	.005	12	view →
DLBC	OS	Quartile	All	0.454	0.879	.002	10	view →
SKCM	DFS	Tertile	II,III,IV	0.506	0.699	.026	9	view →
COAD	DFS	Tertile	IV	1.000	0.262	.029	9	view →
LIHC	DFS	Tertile	III,IV	0.080	0.425	.002	9	view →
SARC	DFS	Tertile	All	0.203	0.363	.026	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 17 lineages.

HMGB1P33–KIRC (OS)

Open the KIRC breakdown →