HMGB1P22

Across TCGA patient cohorts, HMGB1P22 RNA expression is significantly associated with the go_rna of many other GO terms, with 6,058 significant associations in total. STAD shows the largest number of these associations.

The most reproducible HMGB1P22-associated GO terms across cancer lineages are Mitochondrial translation, Peptidyl-lysine monomethylation, and Mitochondrial gene expression. Each is linked with HMGB1P22 in more than 6 cancer types. Because this analysis shows association rather than direction, both HMGB1P22-to-partner and partner-to-HMGB1P22 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Mitochondrial translation grouped by HMGB1P22-low versus HMGB1P22-high in ESCA.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (HMGB1P22→partner) and Y-score (partner→HMGB1P22) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
ESCA	Mitochondrial translation →	+0.078	+0.402	<.001	<.001	3	7
STAD	Peptidyl-lysine monomethylation →	+0.047	+0.251	<.001	<.001	3	6
ESCA	Mitochondrial gene expression →	+0.078	+0.366	<.001	<.001	3	6
ESCA	Regulation of translation at synapse →	+0.048	+0.365	<.001	<.001	3	6
ESCA	Alpha-amino acid metabolic process →	+0.045	+0.200	<.001	<.001	3	6
ESCA	Negative regulation of protein acetylation →	+0.057	+0.172	<.001	.003	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,058 associations by consensus.

Mitochondrial translation by HMGB1P22 expression — ESCA

Explore this box plot interactively →