HMGB1P22

RNA — tumor vs normal
Tumor vs NormalRNABox plot · TCGA cohorts

Across TCGA pan-cancer cohorts, HMGB1P22 RNA differs between tumor and matched normal tissue in 1 of 18 cancer types tested, making tumor–normal expression one of HMGB1P22’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where HMGB1P22 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types HMGB1P22 is over-expressed in tumor.

COAD are the cancer types where HMGB1P22 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in HMGB1P22 RNA (log2); positive values indicate higher expression in tumor. p-values are from the differential-expression test.
LineageGenderStageFold-changepSampling consensus
COADAllII,III,IV+0.173.0442view →
Pink = over-expressed in tumor, green = repressed in tumor. Showing the 1 strongest of 1 lineages.

HMGB1P22–COAD

Tumor-vs-normal expression box plot for HMGB1P22 RNA in COAD.

Open the COAD breakdown →

Exploration