Across TCGA patient cohorts, HMGB1P20 RNA expression is significantly associated with the protein abundance of many other proteins, with 7,551 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible HMGB1P20-associated proteins across cancer lineages are PHF3_S1133, TOP2A_S1377, and TPX2. Each is linked with HMGB1P20 in more than 4 cancer types. Because this analysis shows association rather than direction, both HMGB1P20-to-partner and partner-to-HMGB1P20 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (HMGB1P20→partner) and Y-score (partner→HMGB1P20) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	PHF3_S1133 →	+0.373	+0.376	.006	.008	3	5
UCEC	TOP2A_S1377 →	+0.941	+0.452	.002	.002	3	4
LUAD	TPX2 →	+0.614	+0.227	<.001	<.001	3	4
BRCA	TPX2_S738 →	+0.795	+0.415	<.001	.002	2	5
OV	ZNF638_S1401 →	+0.901	+0.501	<.001	<.001	3	4
BRCA	DDX47 →	+0.373	+0.435	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,551 associations by consensus.

Exploration

HMGB1P20 survival (RNA) · tumor vs normal (RNA) · all HMGB1P20 data types